ea0099p115 | Pituitary and Neuroendocrinology | ECE2024
Campana Claudia
, Amaru Jessica
, Milioto Angelo
, Nista Federica
, M. van Koetsveld Peter
, Iyer Anand
, Arvigo Marica
, Ferone Diego
, J. Hofland Leo
, Gatto Federico
Introduction: Immunohistochemistry (IHC) of somatostatin receptor subtype 2 (SST2) is a predictive factor for first-generation somatostatin receptor ligand (fg-SRL) response in acromegaly patients. A semi-quantitative immunoreactivity score, IRS, has been proposed as the gold-standard to evaluate SST2 IHC expression. Recently, our group developed a quantitative method to determine SST2 expression using an open-source digital image analysis (DIA...